Selective Activation of Retinal Bipolar Cells Using Freeform Electrical Stimulation

Project Aim

This project explores a new method called freeform electrical stimulation to restore vision in people with inherited retinal diseases (IRDs). Unlike current technologies that target retinal ganglion cells, this approach aims to stimulate bipolar cells, which are crucial for processing visual signals. Experts believe this could lead to clearer, more natural vision. If successful, it could pave the way for next-generation vision restoration devices capable of high-resolution sight, enabling people to recognise faces, read, and navigate confidently.

Project Summary

To test this new vision-restoring technique, researchers will combine lab experiments with computer simulations. In the lab, they will study how individual cells in the retina respond to specially shaped electrical signals. At the same time, they will use a detailed virtual model of the human retina to explore how these signals affect different layers of the eye.

This combined approach will help identify the best way to activate bipolar cells safely and effectively, even in eyes affected by disease. The findings will lay the foundation for creating advanced devices that could restore sharp, natural vision for people with inherited retinal conditions.

Expected Outcomes

By the end of the project, the researchers expect to have strong lab and computer-based evidence showing how to control these cells to improve vision. They will also explore how well this works at different stages of vision loss and confirm that the technique does not damage the eye. These findings could lead to the development of next-generation vision-restoring devices for conditions like retinitis pigmentosa, offering people the chance to see more clearly and naturally.