10 October, 2023
Hot Off The Press
…and also in assessing the risks of heart attack, stroke, and Parkinsons Disease among others, just by assessing images of the retina. Pretty cool.
The idea is that this “nanobody” can stabilise the rhodopsin part of a photoreceptor which is unstable in some types of RP. This is in the earliest stages of research but who knows? Anything is possible!
This study reveals for the first time that when the “CERKL gene” is missing, retinal cells are permanently stressed. “This basal exacerbated state means that when additional oxidative damage is caused — as with continuous light stimulation — the cells are no longer able to respond because they can no longer activate antioxidant response mechanisms”.
There are many types of ocular imaging from ocular CT and ocular MRI, to optoretinography, laser speckle flowgraphy, and retinal oximetry. A selection of patients with various IRDs were assessed twice yearly over a period of 6 years with several types of imaging, and also with functional vision testing. Surprisingly, the progression of deterioration did not correlate well between the imaging tests and the functional vision. A wider scope of functional vision tests will help refine the outcomes for research. Then early changes in cone photoreceptors can be used to select emerging therapies for IRDs.