What are the different phases of a clinical trial (for inherited retinal disease treatment)?
These are the earliest trials in the life of a new drug, device or treatment. They are usually small trials, recruiting up to 30 patients. Phase one trials are conducted to determine the safety of a potential treatment. People recruited to phase one trials often have advanced eye disease. These trials must be completed first as safety is the most important issue to resolve before wider testing is undertaken.
This type of trial tests the potential new treatment in a larger number of volunteers to learn more about how the body responds to the treatment, the optimal dose of the treatment and how the treatment affects a certain eye condition. If the results of phase two trials show that a new treatment may be as good as or better than an existing treatment phase three will begin. Better determining the safety of the treatment is also a large component of phase two testing and sometimes phase one and phase two trials are run at the same time.